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新冠病毒的最新研讨来了进犯中枢神经系统演化出两个亚型

2020-03-06 17:28:47  阅读:5648+ 作者:责任编辑NO。蔡彩根0465

新冠肺炎的病例开端在全球多个国家继续添加,关于新冠病毒的研讨也渐渐变得深化。

(图片来自:《每日邮报》网站)

汹涌新闻3月4日报导,北京地坛医院初次报告了新冠病毒进犯中枢神经系统的病例。

A Chinese doctor has warned the novel coronavirus can attack a person's central nervous system. It is the first case that proves the novel coronavirus can damage people's central nervous system, media reported Wednesday.

北京地坛医院官方微博显现,2月25日,56岁的许先生从地坛医院出院。他是一名新冠肺炎危重型患者,一起兼并脑炎。截止3月4日7时,地坛医院累计收治新冠肺炎患者150人,许先生是仅有的新式冠状病毒性肺炎并脑炎患者。

而此前针对SARS(严峻急性呼吸归纳征)、MERS(中东呼吸归纳征)的研讨也均有显现,引发这两种疾病的冠状病毒相同有引起中枢神经系统昂首的事例。

北京地坛医院ICU主任刘景院参加了这名56岁患者的救治,他标明一旦患者呈现认识妨碍,医师应及时进行脑脊液等相关查看,然后进一步下降危重患者的病死率。

Liu Jingyuan, dean of the ICU department of the Beijing Ditan Hospital and attending doctor of the 56-year-old patient, warned that doctors should check cerebrospinal fluid if patients suddenly slip in and out of consciousness, in order to lower the fatality rate of critical patients. The patient recovered and was discharged from hospital on February 25.

该患者于1月24日以新冠肺炎、危重型、呼吸衰竭收入院。医治数日后,医师查看发现患者呈现颌面及口角频频抽搐等神经系统紊乱症状。

The patient was hospitalized one month earlier for respiratory failure. Doctors conducted gene sequencing on his cerebrospinal fluid as he showed symptoms of neurological disorder like twitching on the face after days of treatments.

北京地坛医院重症医学科、检验科及我国疾控中心流行症所联合工作组经过检测查看,终究临床确诊病毒性脑炎。经过一系列针对病毒性脑炎的医治与护理,患者于2月25日恢复出院。

3月3日,国家卫生健康委员会发布了《新式冠状病毒肺炎治疗计划(试行第七版)》,其间指出新冠病毒或许会对包含脑安排在内的器官形成损伤。

China issued the seventh treatment guide for COVID-19 on Tuesday that includes results of autopsies, which clarifies that the novel coronavirus could damage various organs including brain tissue.

一起,针对新冠病毒是否变异的研讨,也是现在学界的焦点。

日前,我国科学团队发现,新冠病毒演化出了两个亚型。

The novel coronavirus has evolved into two major subtypes, a Chinese study has revealed.

3月3日,我国科学院主办的《国家科学谈论》(National Science Review)宣布题为《关于SARS-CoV-2的来历和继续进化》的论文。

The study, titled On the origin and continuing evolution of SARS-CoV-2, was published on the National Science Review of the Chinese Academy of Sciences (CAS) on Tuesday (March 3).

论文经过对现在为止规划最大的103个新冠病毒全基因组分子进化剖析,发现病毒株已发生了149个骤变点,并且多数是近期发生的。该研讨提醒:新冠病毒现已演化出L和S两个亚型。其间101个归于这两个亚型。

By analyzing the genome-wide molecular evolution of 103 novel coronavirus samples, scientists found 101 samples that can be categorized into S-cov and L-cov based on 149 mutation spots on virus strains.

基因组数据标明,感染S型的份额占30%, L型的感染份额占70%。S型与蝙蝠来历的冠状病毒在进化树上更挨近,然后得出S型相对更陈旧的定论。L型在武汉迸发疫情的前期阶段更为遍及。

The paper states that S type, accounting for 30 percent, is closer to the bat-related coronavirus and is relatively older, while the L type was more prevalent in the early stages of the outbreak in Wuhan.

(图片来自:《每日邮报》制作的示意图)

人为干涉或许对L亚型施加了更大的选择性压力,假设没有这些干涉,L亚型或许更具侵略性和分散得更快速。

Human intervention may have placed more severe selective pressure on the L type, which might be more aggressive and spread more quickly than the S type.

不过,论文作者也指出研讨数据很有限。L型怎么从S型演化而来,以及变异怎么影响病毒传达和发病机制,依然是未知数。

However, the authors highlighted the fact the data examined in the study is very limited. How L type strains evolved from S type, as well as how these mutations would affect the transmission and pathogenesis of the virus, are still unknown.

样本显现,大部分患者只感染了L亚型或S亚型中的一个。但其间一位近期有过武汉游览史的63岁美国患者却很有或许一起感染了L型和S型新冠病毒。不过,该论文作者标明现在还无法扫除新骤变型的或许性。

Scientists also found most patients caught either the L or S type of novel coronavirus strain. But there might be exceptions to the rule that should be followed with further research. For example, the study said a 63-year-old female patient in Chicago had likely contracted both L and S types of novel coronavirus strains when she traveled in Wuhan and returned to the United States on Jan 13.

(图片来自:汹涌新闻)

另据新华网报导,巴西研讨人员对病毒基因测序的成果显现,巴西两个确诊病例体内的病毒不一样。巴西阿道弗·卢茨研讨所和圣保罗大学医学院的研讨人员对这两个病例体内的病毒进行了基因测序,成果发现首个病例体内的病毒与在德国发现的病毒愈加类似,而第二个病例体内的病毒则与在英国发现的病毒愈加类似。二者与在我国发现的病毒也不一样。据介绍,这两名患者都是本年2月在意大利感染后回到巴西的。

归纳来历:新华网,我国日报网,CGTN,环球时报英文版网站,汹涌新闻,Daily Mail

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